Yunguang Sun, MD, PhD, Assistant Professor, Pathology & Laboratory Medicine, Medical College of WI.
Research Title: “New therapeutic approaches to estrogen receptor-positive breast cancer
Eighty percent of newly diagnosed breast cancer cases are Estrogen receptor-positive (ER+). More than twenty percent of these patients are projected to die despite anti-estrogen therapy. Currently a lack of effective preclinical models of human Estrogen receptor-positive breast cancer has hampered efforts to find better treatments. Our goal is to develop better human tumor models to test new drugs and treatment options. In our work thus far, we revealed DNA repair pathway
deficiencies in our aggressive patient-derived Luminal B tumor models that could lead to more targeted therapy. Our expectation is that further study will yield insights that can be rapidly adapted to clinical trials for patients with Estrogen receptor-positive breast cancer of the aggressive Luminal B subtype.
Carol L. Williams, PhD, Joan K. Van Deuren Professor in Breast Cancer Research,
Professor, Pharmacology & Toxicology, Medical College of Wisconsin
Research Title: “A novel strategy to suppress the activity of oncogenic small GTPases in breast cancer”
Breast cancer remains a leading killer of women, and our research is aimed at developing better treatments for breast cancer. We are identifying new therapeutic targets that promote breast cancer and developing drugs that inhibit their cancer-causing properties. We discovered that SmgGDS helps breast cancer cells form tumors by activating a group of tumor-promoting proteins called small GTPases.
Our goal is to stop breast cancer cells from using SmgGDS to formtumors. We have developed a promising compound called a splice switching oligonucleotide (SSO) that alters the production of SmgGDSin breast cancer cells. We are exploring the use of this SSO compound as a new strategy to treat breast cancer.
Marja Nevalainen MD, PhD, Professor, Eminent Scholar, Dept. of Pathology and
Pharmacology & Toxicology
Research Title: “Stat5 and Anti-Androgen-Induced Metastatic Phenotype of Prostate Cancer”
Treatment options for metastatic prostate cancer (MPC) are limited to androgen-deprivation-therapy. The new-generation antiandrogen, Enzalutamide dominates the clinical space and is FDA approved in pre- and post-chemotherapy settings. Resistance to Enzalutamide arises within 3-6 months, with patients developing terminal castrate-resistant (CR)-MPC. There are no effective therapies for CR-MPC.
Our data support a novel concept that Stat5 promotes development of Enzalutamide-resistant prostate cancer (ERPC). We previously showed that Stat5 induces metastatic behavior of PC cells. Also, Enzalutamide has been shown to induce metastatic phenotype of PC. Our new data show that Enzalutamide induces Jak2-Stat5 activation in PC. This proposal
will test whether Enzalutamide induction of Jak2-Stat5 signaling in PC mediates Enzalutamide promotion of CR-MPC and may result in a new therapeutic strategy for ERPC by exploiting Jak2-Stat5 pathway inhibitors that are in clinical development for leukemias. Our goal is that this project results in development of a new therapy for ERPC.
The WBCS Scientific Review Committee
Each year, our Scientific Review Committee evaluates proposals from researchers at the Medical College of Wisconsin (MCW) to choose the most promising studies that are aligned with the mission of WBCS. We play an active role as a partner of MCW.